MacDonald completed six years of academic and experiential education, earning her a Doctorate of Pharmacy degree. She graduated cum laude and has since passed the Pennsylvania State Board of Pharmacy exams. MacDonald is now employed as a pharmacist at Western Pennsylvania Hospital in Pittsburgh.
MacDonald graduated from McConnellsburg High School in 2003 and is the daughter of Wayne and Barbara MacDonald. She is the granddaughter of Paul and Jane MacDonald. Paul is also a pharmacist and former longtime owner of MacDonald's Pharmacy, McConnellsburg.